Among the two pairs of hepatitis B, HBsAg HBeAg HBcAb three positive is “major triplet”; HBsAg HBeAb HBcAb three positive is “minor triplet” Major triplet because HBeAg is positive, indicating that the virus is actively replicating in the liver. The small triplet is less harmful than the large triplet, but also has a certain degree of contagiousness Hepatitis B “large and small triplet” is only the difference between the amount of virus, the size of contagiousness, and the level of virus replication. Generally speaking, “minor triple-positive” means less viral load, less infectious, and lower viral replication. The latest scientific research in recent years has found that the onset of hepatitis is related to the hepatitis B virus gene mutation, and some patients with “small triple-positive” have hepatitis B virus gene mutation in the pre-C region, which can lead to aggravation of the disease, commonly due to repeated elevation of serum ghrelin or 1-2 times higher than the normal value. So, is treatment needed for “major and minor triplets”? This often requires further HBV-DNA (i.e. hepatitis B virus nucleic acid polymerase) testing, which is the most direct evidence of viral replication and is an important basis for identifying patients with or without infectious blood. The HBV-DNA test is the most direct evidence of viral replication and is an important basis for identifying whether a patient’s blood is infectious or not, because HBV-DNA (+) is present in a significant proportion of people with “minor triplets”. It is generally believed that this group of people has a mutation in the pre-C region of the hepatitis B virus, which means that there is continuous active replication of the virus in the body, but the test only shows a “small triple-positive” status, which is actually infectious. The clinical management of patients is generally based on the presumed diagnosis: 1. If the liver function is normal, it can be monitored dynamically and checked regularly. Or for those with normal liver function and positive HBV-DNA and after liver puncture, appropriate antiviral therapy. 2.If the liver function is mildly abnormal, it is recommended to take liver-protective drugs or (and) antiviral drugs can play a more satisfactory role in inhibiting viral replication and stabilizing liver function. 3.If the liver function is obviously abnormal, it is better to be hospitalized for systematic treatment, especially for those with jaundice.