Waking up in the morning with numbness in the hand is commonly caused by two diseases, which are basically due to peripheral nerve entrapment. One kind of hand numbness occurs on the side of the thumb, index finger, middle finger and ring finger called radial three and a half fingers numbness, which can be relieved by shaking your hand, and you may wake up with a numb feeling at night. This kind of hand numbness is caused by compression of the median nerve at the wrist, often called carpal tunnel syndrome, which can be treated with local anti-inflammatory treatment and nerve nutrition. If the symptom relief is not obvious and affects daily life, carpal tunnel ligament decompression of the median nerve at the carpal tunnel should be performed to release the nerve, and the postoperative results are very good. Another kind of hand numbness is caused mainly by numbness of the little finger, and this nerve compression occurs behind the elbow joint, which is called elbow canal syndrome. Severe intrinsic hand muscle atrophy, limited fine activity, and claw line hand deformity can occur, and elbow canal release ulnar nerve anterior surgery should be performed as early as possible if conservative treatment is ineffective.