The ward has received three patients who have been taking oral contraceptives for 20 years in the past few months for huge uterine fibroids requiring surgical treatment, and the uterus cut down laparoscopically was more than 2kg. The patients regretted taking the pill for 20 years continuously, can the pill really make fibroids grow like crazy? There are three major types of oral contraceptives on the market today: one is the compound contraceptive containing estrogen and progestin, which is the most widely available on the market, such as MaFuLong, DaYing35, Uthmin, etc. The common contraceptive 1 and 2. Secondly, contraceptive pills containing only progestin can be used as the first choice of contraception for breastfeeding women. New mothers taking this type of pill for contraception will not affect the secretion of breast milk. The third is emergency contraceptive pills containing progestin antagonists, such as mifepristone tablets. If used in the first half of the menstrual cycle, it delays ovulation; if used in the luteal phase, it alters the function of the corpus luteum so that pregnancy cannot occur. It has anti-ovulatory, anti-septal, dilating and softening effects on the cervix, thus aborting early pregnancy, inducing menstruation and promoting cervical maturation. It is generally used in the morning-after pill. It is medically thought that there is a relationship between fibroids and estrogen levels in the body, and that most fibroids will shrink after estrogen suppression. Some birth control pills, such as some combination birth control pills containing estrogen and progestin, have been taken by some patients with uterine fibroids, and the fibroids have increased in size, so many people think that birth control pills can induce fibroids. However, the development around oral contraceptives in the last 40 years or so has been mainly devoted to reducing the content of estrogen. The pill developed in the 1960s had an estrogen content of 150 micrograms with correspondingly high side effects, which were reduced to 50 micrograms in the mid-1970s. All three of the aforementioned patients started taking oral contraceptive 1 20 years ago, the second generation of the pill developed in the 1970s, and the third generation of the pill developed in the 1980s, such as Mafulon, where estrogen was reduced to only 30 micrograms and low doses of estrogen were combined with highly selective progestin to achieve effective contraceptive effects. Some birth control pills, such as Meclizine, now have estrogen levels as low as 20 micrograms. Therefore, doctors believe that such a low level of estrogen should theoretically not induce fibroids, but women who are already found to have fibroids should avoid taking the pill, as it may increase the size of the fibroids. The three patients mentioned above switched to contraceptive methods after regular gynecological examinations during the pill period revealed changes in the uterus so that they did not want the fibroids to grow so large that they regretted it. Women with gynecological malignancies should also not take oral contraceptives, as they may stimulate the malignant transformation of residual trophoblast cells. However, in recent years, it has been found that the pill can reduce the occurrence of benign lesions such as lobular hyperplasia and breast fibroids. There is a pill that can also treat fibroids, and emergency contraceptives containing progestin antagonists, such as mifepristone tablets, can also treat fibroids, which can shrink after taking mifepristone. The fact that many women are apprehensive about the pill, such as thinking it will make them fat, have an effect on future pregnancies, and may induce fibroids, emergency contraceptives account for 2/3 of the overall share of contraceptives in China. this is related to the severe lack of knowledge about the use of the pill among women. In fact, with the improvement of technology, the current contraceptive pill has been extraordinarily safe and effective.