Pregnancy is a special period of time, especially the first trimester, is a critical period of fetal development, it is easy to accidentally lead to miscarriage, at this time should be strengthened nutrition, sleep, avoid strenuous exercise, avoid fatigue, avoid staying up all night, avoid sex and so on. The first trimester of pregnancy specific appropriate and contraindicated matters are as follows: 1, supplemental folic acid: 1-3 months before pregnancy need to supplement folic acid, the lack of folic acid can easily cause fetal neural tube developmental defects, malformations, cleft lip and palate, but also increase the incidence of spina bifida, in addition, the serious cases can cause spontaneous abortion. 2, balanced nutrition: some pregnant women due to severe pregnancy reaction, there will be morning sickness, nausea, loss of appetite, picky eaters and other phenomena, easy to nutritional imbalance, serious can also lead to pregnant women’s body acid-base imbalance, affecting the healthy development of the fetus, the normal diet can be supplemented with the required protein and calories, and should also be moderate to eat some fruits and vegetables, coarse grains, etc., balanced nutrition. 1, avoid coitus: avoid coitus in the first trimester of pregnancy, at this time the placenta is not yet fully developed, the connection between the placenta and the wall of the uterus is not yet close, if coitus will stimulate the uterus to contract, is not conducive to the development of the embryo bed, and in severe cases, will lead to preeclamptic abortion. 2, avoid staying up late: pregnancy consumes blood, easy to fatigue, tired, at this time if also stay up late, easy to cause blood loss. At the same time, the normal development of the fetus height, weight and other adverse effects.