Somatic jaundice is a chronic jaundice caused by congenital impaired uptake, binding or excretion of bilirubin by hepatocytes, mainly manifesting as long-term persistent or fluctuating jaundice, mild or asymptomatic and mostly normal liver function. Somatic jaundice is also known as somatic hyperbilirubinemia and hereditary hyperbilirubinemia. It is rarely seen clinically. Based on the nature of the increase in serum bilirubin, it can be divided into two main categories, namely jaundice with predominantly unconjugated bilirubin (hyperunconjugated bilirubinemia UCHB) and jaundice with predominantly conjugated bilirubin (hyperconjugated bilirubinemia CHB). Somatic jaundice is often misdiagnosed as chronic hepatitis or chronic biliary disease due to the presence of persistent or fluctuating jaundice over a long period of time, and there are even mistakenly unnecessary surgeries. The clinical differentiation from other types of jaundice is very important, as it relates to treatment and prognosis. The key to the diagnosis of this type of jaundice is to have a basic concept of it. Any clinical encounter with chronic jaundice with mild clinical symptoms, a course of disease that is different from the general pattern of viral hepatitis, hemolytic jaundice and biliary disease, and normal liver function tests except for abnormal bilirubin metabolism, especially when there is a family history, should always be considered for this type of rare jaundice. General somatic jaundice has four characteristics: 1. Most have a family history or genetic predisposition; 2. Clinical symptoms are mild or asymptomatic, mainly showing chronic fluctuating jaundice; 3. Liver function is normal except for elevated serum bilirubin; 4. Outside of Griger-Najjar, most do not require treatment and have a good prognosis.