In newborns, jaundice can be classified as physiological jaundice, breast milk jaundice, or pathological jaundice. For physiological jaundice and breast milk jaundice, this is a normal physiological reaction and does not usually affect BCG vaccination. If there is no progressive worsening of jaundice and no clinical abnormalities, this is considered physiological jaundice and it is recommended that BCG vaccination be considered when the jaundice value is below 8-10 mg/dl, which is safer and will not cause clinical side effects. In pathological jaundice, the value of jaundice may increase significantly and may even reach more than 20 mg/dl, with the risk of bilirubin encephalopathy. Therefore, prompt treatment of the primary disease is required at this time, in some cases by medication and in others by surgery. Vaccines such as BCG should not be administered until the jaundice is controlled.