Tinnitus is a common symptom of otolaryngology caused by a variety of reasons. It is a subjective sensation that patients can hear themselves without a corresponding source of sound from outside. Glutathione is only an adjunctive medication, and it is not possible to treat any cause of tinnitus. Tinnitus is not only caused by diseases of the ear itself, but also by other diseases of the body, and psychosomatic factors can also cause tinnitus symptoms. Glutethimide is mainly used as an adjuvant medication for the treatment of periodic psychosis and various neuroses. If a patient’s tinnitus is caused by psychosomatic factors, he or she can use glutethimide for adjuvant treatment. Clinical tinnitus can be caused by various foreign bodies in the external ear canal; also fungal otitis externa, as well as cholesteatoma of the external ear canal, and tinnitus caused by cerumen embolism in the external ear canal. Various diseases of the middle ear are also common causes of tinnitus. However, the most common type of tinnitus is sensorineural tinnitus of unknown origin, which is also the most difficult to treat. All of these tinnitus cannot be treated with glutathione. If the tinnitus is caused by menopause or sensorineural tinnitus, which leads to reduced sleep quality and psychological problems, it can be treated with glutamate. To treat tinnitus, it is important to find the cause of the tinnitus and treat the cause of the tinnitus in order to provide effective treatment.