Wake up at 2:30 in a row chest tightness during the day is fine, should go to the hospital in time for systematic examination, may be myocardial blood supply insufficiency, cardiac neurosis, arrhythmia, anemia or other diseases. 1. Insufficient blood supply to the myocardium: for example, insufficient blood supply to the myocardium caused by coronary artery disease and other reasons, there may be sudden symptoms, which may be manifested in the chest tightness of waking up at 2:30 consecutively, but nothing during the day. 2. Cardiac neurosis: Exhaustion, mental stress, and malfunctioning of nerve function may cause cardiac neurosis, and such symptoms may occur. 3. Cardiac arrhythmia: Various types of cardiac arrhythmia may cause changes in the regularity of the heartbeat and may cause related symptoms. 4. Anemia: Anemia may cause fatigue, dizziness, and increased heart rate, and may cause symptoms at night and normal symptoms during the day. 5. Other diseases: hyperthyroidism, hypertension and other chronic diseases, if there is an acute attack of the disease, may appear at night chest tightness. Continuous 2:30 wake up chest tightness during the day is fine, there may be other reasons, it is recommended to go to the hospital in a timely manner to check, so as to further clarify the cause of the disease.