What are the clinical manifestations of Marfan’s syndrome? 1, the skeletal muscle system mainly has elongated limbs, spider fingers (toes), arms flat finger distance greater than the length of the body, hands sagging over the knee, the upper body is longer than the lower half of the body. Long head deformity, narrow face, high palatal arch, large and low ears. Little subcutaneous fat, underdeveloped muscles, wrinkled skin on the chest, abdomen and arms. The muscle tone is low, with an inert body type. Ligaments, tendons and joint capsules are elongated and lax, and joints are hyperextended. Sometimes funnel chest, chicken chest, kyphosis, scoliosis, spina bifida, etc. are seen. 2. The eyes mainly have crystal-like dislocation or subluxation, high myopia, cataract, retinal detachment, iris tremor, etc. There are more males than females. 3.Cardiovascular system about 80% of patients with congenital cardiovascular anomalies. Progressive aortic dilatation, aortic valve closure insufficiency, aortic sinus aneurysm due to cystic necrosis of the middle layer of the aorta, intercalated aneurysm and rupture are common. Mitral valve prolapse and mitral valve insufficiency are also important manifestations of this syndrome. It can be combined with congenital atrial septal defect, ventricular septal defect, tetralogy of Fallot, patent ductus arteriosus, and aortic constriction. It can also be combined with various arrhythmias such as conduction block, pre-excitation syndrome, atrial fibrillation, atrial flutter, etc.