1, most patients first appear numbness and heaviness in one or both lower limbs, then gradually appear difficulty in walking, tightening of the muscles in each group of lower limbs, slow to lift the step and unable to walk fast. Then, when going up and down the stairs, it is necessary to hold the puller with the upper limbs to ascend the steps. In severe cases, the gait is unstable and walking is difficult. Patients have the feeling of stepping on cotton in both feet. Some patients start insidiously, often trying to catch a bus that is about to leave, but suddenly find that the legs cannot walk fast. 2. Numbness and pain in one or both upper limbs, weakness and inflexibility in both hands, difficulty in completing fine movements such as writing, fastening, holding chopsticks, etc., and easy to drop objects. In severe cases, the patient cannot even eat by himself. Patients often feel a belt-like binding sensation in the chest, abdomen, or both lower limbs, called “belt sensation”. At the same time, there may be burning and cold sensation in the lower extremities. 4. Some patients have bladder and rectal dysfunction. Such as weak urination, frequent urination, urgent urination, incomplete urination, urinary incontinence or urinary retention and other urinary disorders, constipation. Sexual function is reduced. Further development of the disease, the patient must be crutches or with the help of others to walk, until the emergence of spastic paralysis of both lower limbs, bedridden, unable to take care of themselves. 5. Clinical examination: There are no physical signs in the neck. The upper extremities or trunk have segmental distribution of superficial sensory disorders, deep sensation is normal, muscle strength is reduced, and grip strength of both hands is reduced. Tendon reflexes are active or hyperactive: including biceps, triceps, radial membrane, knee tendon, Achilles reflex; patellar clonus and ankle clonus are positive. Positive pathological reflexes: such as Hoffmann’s sign, Rossolimo’s sign in the upper extremity, Barbinski’s sign and Chacdack’s sign in the lower extremity. Superficial reflexes such as abdominal wall reflex and tic reflex were diminished or absent. If the tendon reflexes of the upper extremity are diminished or absent, it suggests that the lesion is at the level of that nerve segment.