After the swelling and pain in the tooth bed, a large part of it is caused by the infection factor, and usually some antibiotics can be chosen for the treatment. The choice of antibiotics also needs to be used wisely, mainly related to the oral environment where the inflammation occurs. The main choice of antibiotic treatment is to choose metronidazole, amoxicillin or some cephalosporins for treatment. Metronidazole has long been considered as an effective drug for the treatment of anaerobic bacteria. Amoxicillin and cephalosporins are more commonly used broad-spectrum antibacterial drugs. These drugs are not only inexpensive and commonly used clinically, but also have relatively good effects. Anti-inflammatory drugs must be chosen rationally. Inappropriate drug selection can cause many problems. Drug resistance is mainly caused by incorrect selection of antibiotics and too prolonged use of antibiotics. Gram-positive bacteria in the oral cavity as well as anaerobic bacteria cause most infections, the choice of anti-Gram-negative bacteria drugs, the treatment effect will not be good, too much to kill some other bacteria in the oral cavity, may lead to the growth of some other bacteria, the occurrence of lesions, and then use the commonly used metronidazole these drugs may not be effective. Drug selection should also pay attention to the issue of whether it is allergic, which is the focus of a reasonable choice of antibiotics, allergic cephalosporin antibiotics, penicillin use, the lighter can appear rash itching discomfort, the heavier can be life-threatening. The use of antibacterial drugs should be cautious, it is recommended to use under the guidance of a doctor. The oral cavity is a relatively closed, accessible environment. This environment can easily lead to the growth of anaerobic and gram-positive bacteria. In some cases, the blind use of antibiotics can lead to more serious consequences. On the one hand, a doctor should be consulted, and on the other hand, topical treatment of the oral cavity often has better results than antibiotics.