After clear blisters on the feet, there is usually a slight pain, you can first observe and preliminary analysis of the causes, if necessary, timely medical treatment, according to the different causes, treatment methods are also different. 1, friction: friction stimulation caused by large blisters is one of the most common causes, you can use iodophor disinfection, after disinfection with a sterile syringe to extract the bubble solution, local topical boric acid solution, generally large bubble dry can be Cure, while avoiding further frictional stimulation; 2. Infection: usually secondary to eczema or fungal infection of the feet, can produce clear blisters, as eczema tends to cause local blisters and vesicles, while fungal infection of the feet, also known as tinea pedis, can produce blisters and vesicles, and if care is not enhanced, bacterial infection can develop secondary to the blisters, which can turn into pustules. If the blisters are caused by fungal infection, you can apply topical antifungal medications such as naftifine ketoconazole cream or terbinafine hydrochloride cream, etc. After the blisters subside, you need to consolidate the treatment for 1 week again; 3. Allergy: As the patient’s feet show allergy symptoms, capillaries dilate, leading to the release of acetylcholine in the body, which in turn then stimulates the human mast cells to degranulate and release allergy mediators such as histamine and leukotrienes, leading to allergy. Oral antihistamines, such as levocetirizine hydrochloride capsules and loratadine citrate capsules, along with glycopyrrolate capsules and topical ointment hydrocortisone butyrate, are required for treatment. Patients should avoid repeated rubbing of the affected area during treatment, pay attention to keeping it clean and dry after treatment to prevent secondary infection, avoid stimulating the wound with hot water, and wear light and breathable cotton shoes and socks to facilitate wound recovery. Note that no spicy food should be consumed in the near future, and pay attention to protein and vitamin supplementation to facilitate wound recovery. At the same time, it should be noted that if a relatively small blister appears on the foot, do not pick it and wait for the blister to be absorbed naturally, no special treatment is needed. You should try to wear loose shoes to avoid rubbing and squeezing of the affected area, and it is recommended to reduce activities to avoid pain, as well as to minimize water exposure to prevent wound infection.