The causes of hiccups without eating are mainly seen in the following: 1. Stimulation of the phrenic nerve: These include mediastinal tumors, esophageal tumors, aortic aneurysms, and esophagitis. Hiccups can also occur in the presence of pneumonia, pleurisy, pericarditis, and esophageal hiatal hernia. It is mainly caused by lesions in these areas that irritate the phrenic nerve and lead to spasm of the diaphragm. The treatment for hiccups caused by tumors requires surgery. Hiccups caused by infections in surrounding tissues and organs require anti-infection treatment to reduce the stimulation of the phrenic nerve. 2. Central neuropathy: mainly seen in intracranial occupations, cerebral infarction, cerebral hemorrhage, encephalitis, and alcoholism, etc. Hiccups occur mainly due to compression or stimulation of the central nerve that governs the phrenic nerve. The main treatment is surgery to treat intracranial occupations and other factors that compress the central nerve.