The treatment methods of trigeminal neuralgia include medication, local closed therapy, surgery and other ways, generally preferred medication, the efficacy is generally better, surgical treatment is often radical treatment, but there are certain trial symptoms and complications, patients should choose under the guidance of professional physicians according to the patient’s condition, physical condition and so on. Drug therapy: Treatment drugs include carbamazepine, phenytoin sodium, lamotrigine, baclofen and other drugs, which should be started in small doses and maintained with the lowest effective dose as much as possible. Common adverse effects of taking drugs include dizziness, drowsiness, nausea, dyspepsia, unstable walking, occasional rash, leukopenia, liver function impairment, etc. The dosage of drugs should be monitored and rechecked regularly during taking drugs to adjust the dosage to achieve the best treatment effect. Closure therapy: For those who are ineffective in drug treatment or have obvious side effects, refuse surgical treatment or are not suitable for surgical treatment, anhydrous alcohol or glycerin can be used to close the trigeminal nerve branches or the semilunar ganglion to destroy the sensory nerve cells, which can achieve the effect of pain relief. The adverse effect is the loss of facial sensation in the injection area. Surgical treatment: including trigeminal nerve sensory root partial excision or gamma knife treatment, the pain relief effect is exact. In recent years, trigeminal nerve microvascular decompression is mostly used, which can achieve pain relief without cutting the nerve, but complications such as hearing loss, air embolism and temporary paralysis of facial nerve may occur. In conclusion, surgical treatment is the radical method for trigeminal neuralgia, but patients should choose the appropriate treatment plan according to their condition under the guidance of professional physicians.