The most effective premature ejaculation medicine varies from person to person, clinically commonly used drugs for the treatment of premature ejaculation are divided into surface local anesthetics and oral medication, etc.. 1. Surface local anesthetic, commonly used in the clinic is lidocaine-proparacaine spray, is a safe and effective way to treat premature ejaculation, individual patients with too much dosage will produce erectile difficulties. 2. Oral drugs, mainly tramadol, 5-hydroxytryptamine reuptake inhibitor (dapoxetine) and so on. Dapoxetine’s adverse effects are relatively mild and mostly tolerable, and it is currently the first-line clinical treatment of premature ejaculation, but the reproductive toxicity of the drug is not yet fully understood. There are also fluoxetine, paroxetine and so on. All of the above are drugs for the treatment of premature ejaculation, but it is not recommended that patients buy and use on their own, so as not to cause serious adverse consequences, should be strictly in accordance with the doctor’s instructions to buy and use as needed.