The appearance of pustules on the patient’s feet may be caused by bacterial infection or by palmoplantar pustulosis, which is more commonly seen clinically in these two conditions. In addition, it may also be associated with connective tissue diseases, etc. It is recommended to seek medical attention promptly to treat the cause.1. Bacterial infection: usually secondary to eczema of the foot or fungal infection of the foot, blisters and vesicles will appear, and if care is not enhanced, bacterial infection will develop secondary to the blisters, and the blisters will become pustules. Clinical need for surgical excision and incision and drainage, postoperative can be static penicillin sodium or clindamycin phosphate injection for antibacterial treatment, while the local application of potassium permanganate solution repeatedly rinse the affected area, and then apply mupirocin ointment for treatment; 2, palmoplantar pustulosis: a kind of psoriasis, belongs to the aseptic inflammation, pustules mostly occur on the soles of the feet, repeatedly appear in batches, preferably in 50-60 years old Middle-aged and elderly women, most patients relapse or aggravate in winter and relieve in summer. Treatment of palmoplantar pustulosis includes symptom control, improvement of the patient’s quality of life, and graded treatment according to the severity of the patient’s disease. Clinically, drug therapy or physical therapy is usually used. Drug therapy includes cyclosporine, retinoic acid, and glucocorticoids; physical therapy includes photochemotherapy and hydrotherapy. However, the current effective treatment can only achieve the recent effect and cannot prevent recurrence; 3. connective tissue diseases: when the abscesses show a wide distribution and are relatively easy to break may be caused by connective tissue diseases, such as aspergillosis or aspergillosis-like knots, and need to go to the hospital for diagnosis and treatment in a timely manner.