Patients with numbness in the hands and weakness in the legs are firstly caused by cardiovascular diseases, for example, patients with heart failure resulting in insufficient cardiac output, patients will have symptoms of peripheral circulation disorders, and this time patients will experience numbness and weakness. Secondly, it may also be caused by the patient’s coronary artery blockage, atherosclerosis, myocarditis, myocardial infarction and many other causes, and it may also be caused by vertebral diseases, such as spinal stenosis, vertebral osteitis, cervical spondylosis, lumbar disc herniation and many other diseases. In addition, it may also be caused by lesions in the patient’s brain, such as damage to cortical functional areas, brain tissue necrosis, and many other causes. Patients can go to the hospital for further examination and early treatment to avoid aggravation, and patients should also go to the hospital for regular review to avoid relapse of the patient’s condition.