Drugs that block the brain’s ejaculation commands generally refer to drugs that delay ejaculation, and can be categorized into oral drugs as well as topical drugs, such as dapoxetine, paroxetine, lidocaine gel, and so on. 1. Oral drugs: 5-hydroxytryptamine reuptake inhibitor drugs such as dapoxetine can improve the level of pentazocine in the brain and increase the neural mediators, thus prolonging the ejaculation time. 2. Topical drugs: you can choose to use local topical application of anesthetics, such as lidocaine gel, etc., which can prolong ejaculation time by reducing the sensitivity of the glans penis. In addition to the above mentioned drugs to delay ejaculation, there are many other effective oral or topical drugs, before using the drugs need to go to the hospital and ask the doctor’s professional opinion.