There is no such thing as the best way to remove moles from the skin, and it is recommended that patients take physical therapy, surgery and other ways to remove them. 1. Physical treatment: laser treatment is one of the common treatment methods, such as Q laser, fractional laser, etc., which is suitable for smaller pigmented moles, and it can utilize high-energy laser to destroy pigment particles, so as to achieve the effect of removing moles on skin. 2. Surgical treatment: If the mole is large in size or has the tendency of malignant transformation, it can be given surgical treatment, such as surgical excision, but the local skin may leave a certain degree of scarring. If you need to remove moles on the skin, it is recommended to go to a regular hospital and choose an appropriate way under the guidance of the doctor.