There are many causes of oral palate blistering, which may be caused by bacterial infection or viral infection. For oral palate blisters caused by bacteria, you can apply topical mouthwash, such as Rehabin solution, Chlorhexidine solution, Tinidazole solution, etc. You can also apply sprays, such as stomatitis spray, open throat sword spray, etc. In the case of oral palate blisters caused by viral infections, topical application of mouthwash and sprays along with antiviral treatment is required. For oral palate blisters, in addition to the application of local and systemic drugs, it is also necessary to maintain good oral hygiene, not to eat spicy and stimulating food, and to eat more vitamin-rich food to enhance nutrition. Drink more water and pay attention to rest. If the upper jaw of the mouth is simply a single large vesicle, it is necessary to take an ultrasound to determine whether there is a swelling in the upper jaw. If a cyst or tumor is formed, surgery may be required. If the blister is traumatic, the blister may need to be opened to release the blood and treated with local anti-inflammatory therapy. The cause of oral blistering must be thoroughly identified and treated accordingly.