Five pregnancies and five miscarriages happened to 33-year-old Ms. Wang, and after screening various factors such as gynecology and endocrinology, the problem was solved in the rheumatology department, and finally a clear diagnosis of antiphospholipid antibody syndrome was made. Antiphospholipid syndrome, is not uncommon. Once suffering from this disease, blood clots tend to form in a person’s body, especially in women during pregnancy, when microthrombi form in the placenta at about 10 weeks of pregnancy, causing insufficient blood supply to the placenta and leading to repeated miscarriages. I. What is antiphospholipid syndrome? It is a non-inflammatory autoimmune disease associated with “antiphospholipid antibodies” and is a common acquired thrombophilia. Simply put, antiphospholipid antibodies can be detected in patients with antiphospholipid syndrome, and the presence of such antibodies can easily lead to the formation of blood clots in humans. The presence of antiphospholipid antibodies can easily lead to thrombosis in humans. There are 3 types of morbid pregnancies in which antiphospholipid syndrome is suspected: 1) ≥1 unexplained intrauterine fetal death at ≥10 weeks of gestational age (normal fetal morphology confirmed by ultrasound or direct examination); 2) ≥1 preterm birth before 34 weeks of gestation (normal neonatal morphology), the causes of preterm birth include: (1) eclampsia or severe pre-eclampsia; (2) placental insufficiency. 3. ≥3 consecutive unexplained spontaneous abortions before 10 weeks of gestation, excluding maternal anatomy, hormonal abnormalities and chromosomal abnormalities in both parents. 3. Can’t I get pregnant if I have antiphospholipid syndrome? It is not absolute. With reasonable treatment, the condition can be controlled during pregnancy and a healthy baby can be born. The treatment of antiphospholipid syndrome mainly includes the following aspects: 1. Reduce the risk factors of thrombosis. These risk factors include smoking, oral compound contraceptives, long-term bed rest, etc. 2.Treat the primary disease. The rheumatic disease most likely to be combined with antiphospholipid syndrome is systemic lupus erythematosus. Controlling the condition of lupus is also beneficial to the treatment of antiphospholipid syndrome. 3. The treatment of antiphospholipid syndrome itself, with anticoagulation therapy as the basic, should be carried out under the guidance of a specialist. Finally, we remind you that there are many causes of recurrent spontaneous miscarriage in pregnant women. If some common causes such as gynecological problems and endocrine hormone problems are ruled out, you must think more about whether it is a problem of the autoimmune system. Especially if there are immediate family members with autoimmune diseases in the family, it is more important to consider this disease. Pregnant mothers with autoimmune diseases do not need to be particularly worried, as they can have a successful pregnancy after six months of stabilization and stopping the use of immunosuppressive drugs that affect the fetus, but they need to be closely monitored by a doctor. It is also necessary to insist on follow-up after delivery and to regularly test the body’s immune level to prevent the occurrence of unexpected events such as recurrence of the disease, miscarriage, premature delivery and blood clots.