Patients wake up in the middle of the night with numb hands, mainly consider the following causes: 1, may be because the patient’s limb pressure leads to local blood circulation is not smoothly caused, if patients always keep a side lying position, limb pressure may appear hand numbness. 2, patients wake up in the middle of the night with numb hands, to consider related to cervical spondylosis. Because the patient if there is a cervical spine do physiological curvature straightening, disc protrusion and other problems. When the patient sleeps in an improper posture, or in the case of unsuitable bedding for sleep, it is easy to cause the intervertebral disc to compress the protruding nerve root, which will lead to the problem of hand numbness. 3, the patient wakes up in the middle of the night with hand numbness, if accompanied by numbness of the limbs, trunk, face, to consider may be caused by cerebral thrombosis, this situation must be timely medical consultation.