Chronic diarrhea and intestinal infections, inflammatory bowel disease and other digestive diseases, but also with hyperthyroidism, irritable bowel syndrome and other systemic diseases, the specific treatment drugs need to be based on the cause of the disease, the treatment of chronic diarrhea of the drugs are anti-infective drugs, aminosalicylic acid preparation, glucocorticosteroids and so on. 1. Digestive system diseases (1) Intestinal infections: for chronic enteritis, chronic bacillary dysentery, intestinal tuberculosis and other infectious chronic diarrhea caused by intestinal infections, the treatment needs to be directed at the pathogenic bacteria for anti-infective treatment, such as norfloxacin, levofloxacin, ornidazole and so on. (2) Inflammatory bowel disease: including ulcerative colitis, Crohn’s disease, belonging to the intestinal non-infectious diseases. Treatment can be given to aminosalicylic acid preparations, glucocorticosteroids, biological agents to relieve symptoms, such as lorazepam, methylprednisolone, azathioprine. 2. Systemic diseases (1) Hyperthyroidism: It is a group of clinical syndromes caused by excessive thyroid hormone in blood circulation, which leads to increased excitability and hypermetabolism in circulatory, digestive and other systems. Patients may have hyperphagia, diarrhea and other digestive symptoms, and need to follow the doctor’s instructions to use anti-thyroid drugs, such as propylthiouracil. (2) Irritable Bowel Syndrome (IBS): a functional intestinal disease characterized by abdominal pain and changes in bowel habits. Patients with diarrhea can follow the doctor’s instructions to use loperamide, montelukast, etc. to relieve symptoms. There are many other causes of chronic diarrhea, it is recommended to consult a doctor to clarify the cause of the targeted treatment, so as not to delay the condition.