The Joint Disease Treatment Center of Peking University People’s Hospital has applied the computer simulation navigation system to total knee replacement, which greatly reduces the surgical error rate, can extend the service life of the prosthesis, and improves the success rate of the surgery. In traditional TKR surgery, the surgeon performs 3D imaging and preoperative surgical simulation in his or her own brain to determine the surgical plan, and the quality of the surgery often depends on the individual surgeon’s surgical clinical experience and skills. In contrast, the computerized navigation system is a computerized process that takes the imaging data obtained before and during surgery and forms a three-dimensional visual image, so that the most suitable size joint parts can be automatically selected before surgery to simulate opening, and during surgery, sensors are placed on the bone, and the navigation system has an infrared camera that dynamically tracks the real-time spatial position relationship of the surgical instruments relative to the patient’s anatomical structure, according to which the surgeon can precisely place the The surgeon can then accurately place the artificial joint. Recently, three patients with osteoarthritis of the knee have undergone total knee arthroplasty with this system at the Joint Disease Center of Peking University People’s Hospital, and the procedure went smoothly with good recovery and high satisfaction. Computer-assisted total knee arthroplasty is an emerging discipline with potential advantages. With the accumulation of experience and improvement of the navigation system, it will become a standard intraoperative aid for knee reconstruction surgery and can also be used for secondary knee and hip replacement and spine surgery fracture surgery.