Since the release of the movie “Do Not Disturb II”, there are many people who go to the hospital to see moles and consult with them, but in fact, mole malignancy can be initially checked by yourself. The signs of mole malignancy are simply summarized as “ABCDE” five points: A stands for Asymmetry B stands for Border irregularity C stands for Color variegation D stands for Diameter greater than 6mm ( Diameter) E stands for Evolving Diameter) E represents the progress (Evolving) These signs should go to the hospital dermatology. Also note: 1. Pigmented nevi in friction areas, especially in the palms of hands and feet, are recommended to be removed. Malignant melanoma in Chinese is predominantly in the extremities. 2. For small moles that can be easily removed, laser and freezing are available. However, they should be removed cleanly, otherwise repeated stimulation may lead to malignant transformation. Large moles are best selected for surgical excision.