Fat grains, medically known as milia, are epidermal cysts caused by breaks in the epidermis of the skin. Long-growing fat grains can be removed by methods such as picking or laser treatment. The skin in the area of the granule can be sterilized and cleaned, and then a small sterile needle can be used to puncture the granule and remove the contents. Erythromycin ointment can be applied after picking out to prevent infection. It should be noted that this operation should be carried out in the hospital by a doctor, do not do it by yourself to avoid adverse reactions. The formation of a long time of stubborn fat grain can go to the hospital to do laser to remove it, generally will not cause too much damage to the skin, relatively safe and reliable. If the patient does not find relief from the fat grain for a long time or accompanied by other symptoms, it is recommended to go to the hospital for early and regular treatment. Unauthorized use of medication should be avoided to avoid adverse consequences.