In recent years, about 2,400 or more people die each year in China due to rabies, ranking second in the world after India. Rabies is an ancient disease in which people are bitten, scratched or licked by an animal with or suspected of having rabies (dog bites are the most common), and is an acute infectious disease of the central nervous system caused by rabies virus infection, which is currently the disease with the highest death rate in the world. Currently more and more people keep pets, but only few people take the initiative to vaccinate their pets against rabies, so the incidence of rabies is on the rise in China and must be taken seriously. When a person is bitten or scratched by a host animal such as a dog or cat, a thorough cleaning and disinfection of the injured area should be carried out immediately. The earlier the local wound treatment, the better. Wound treatment is not advocated if the wound has already crusted or healed at the time of consultation. I. Wound treatment Wound treatment, including thorough rinsing and disinfection treatment, is important for the prevention of rabies. First, the mechanical force of water rinsing can help reduce the amount of virus residue in the wound; more importantly, rabies virus is more sensitive to lipid solvents (soap and water, chloroform, acetone, etc.), 75% alcohol, iodine preparations, and quaternary amines. Therefore, thorough wound irrigation and disinfection can greatly reduce the risk of infection in exposed individuals. Rinse thoroughly Rinse the wound thoroughly with soapy water or water for at least 15 minutes. 2. Disinfection After thorough irrigation, apply 2-3% iodine or 75% alcohol to the wound. 3.Wound treatment after rinsing and disinfection (1)As long as the large blood vessels are not injured, try not to suture and should not be bandaged. (2) when the wound is large or facial heavy injury affects the face, really need to suture, after doing debridement and disinfection, should first use animal-derived antiserum or human-derived immunoglobulin for infiltration injection around the wound, so that the antibody infiltration into the tissue to neutralize the virus. After a few hours (no less than 2 hours), sutures and dressings should be applied; for larger wounds to avoid secondary infection, a permeable dressing should be used to cover the wound. If necessary, the sutures should also be loose and sparse to allow for continued drainage. (3) Deeper wounds and serious contamination should be treated with anti-tetanus and antibiotics as appropriate to control other pathogenic microbial infections. (4) Go to hospital for further treatment as early as possible.