Causes of blistering at the corners of the mouth include burns, viral infections, and bacterial infections, among which erythromycin ointment can be used for blistering at the corners of the mouth caused by bacterial infections. When blistering at the corners of the mouth is caused by bacteria, mycoplasma, chlamydia and other pathogenic bacteria, the symptoms can be improved by applying erythromycin ointment locally. However, if the blisters are caused by bad habits, they can be treated by adjusting lifestyle habits, specifically recommended to avoid staying up late, eat a light diet, quit smoking and drinking. If you have burns on the corners of your mouth, you can pick the blisters, pay attention to cleanliness to promote wound healing, herpes simplex virus infection caused by blisters on the corners of the mouth can be applied locally antiviral drugs, such as acyclovir ointment treatment. Due to the diversity of causes and individual differences, the drug does not exist absolute effective safety, it is recommended that under the guidance of a doctor to standardize the use of adverse reactions, it is recommended to consult a doctor, drug allergy is prohibited.