”Medicine is really a field where knowledge is constantly being updated and studying medicine is really a profession that requires constant learning.” This was a great feeling after I read the guidelines for the prevention of mother-to-child transmission of hepatitis B virus. There really are so many changes! Do you understand the differences between the latest current guidelines and the previous ones? Would you still recommend pregnant women with hepatitis B virus to get tested for HBV DNA to decide whether to breastfeed? Previous opinion 1. The use of hepatitis B immunoglobulin (HBIG) during late pregnancy can prevent mother-to-child transmission. 2. You cannot breastfeed if you have hepatitis B major triplet (hepatitis B surface antigen HBsAg, hepatitis B e antigen HBeAg, hepatitis B core triplet positive) or HBV DNA greater than 106. The latest opinion 1, the use of hepatitis B immunoglobulin in late pregnancy has no effect on the prevention of mother-to-child transmission. 2, regardless of hepatitis B major triplet or minor triplet (hepatitis B e antigen HBeAg negative), as long as the regular prevention, can breastfeed, no need to test the milk for HBV DNA! How to regular prevention? 1, Hepatitis B vaccination is the most effective measure to prevent HBV infection. 2.When pregnant women are HBsAg negative, full-term newborns should be vaccinated with hepatitis B vaccine according to the “0,1,6 months” program, without using hepatitis B immunoglobulin. 3.When the pregnant woman is HBsAg positive, the full-term newborn will be vaccinated with hepatitis B vaccine according to the “0,1,6 months” program, and hepatitis B immunoglobulin will be injected within 12 hours after birth. 4.If the HBsAg of the pregnant woman is unknown, it is recommended that the newborn be injected with hepatitis B immunoglobulin if available.