Rifampicin is a bactericidal drug mainly used in the treatment of tuberculosis. Rifampicin inhibits the synthesis and transcription of bacterial RNA, which can kill Mycobacterium tuberculosis as well as some other mycobacteria, such as Mycobacterium leprae, etc. It also has a certain antimicrobial effect on pathogens such as Staphylococcus aureus, Legionella pneumophila, Haemophilus influenzae, and Streptococcus epidermidis. The oral absorption rate of rifampicin is very high, up to 90%-95%, and the effective concentration can be maintained for 6 hours after oral intake. In addition to the main treatment of tuberculosis, it can also be used for the treatment of leprosy, legionella pneumonitis, osteomyelitis, endocarditis and so on. Rifampicin is toxic to the liver and may cause gastrointestinal reactions such as abdominal pain, diarrhea, nausea, vomiting, etc. It should be used with caution in children, liver disease and pregnant women. The drug should be taken under professional medical supervision.