This refers to inflammation of the iris, ciliary body, and choroid. The iris and ciliary body are supplied with blood from the same large ring of the iris, so they are often inflamed at the same time and are collectively referred to as iridocyclitis; if the choroid is also inflamed at the same time, it is referred to as uveitis. Chromatophoresis is the most common extra-articular manifestation of spondyloarthropathies and is primarily due to an immune response. It predominates in males. Most often both eyes are involved, usually one eye at a time, with alternating episodes, but also both eyes at the same time. Acute iridocyclitis associated with ankylosing spondylitis typically presents with ocular pain, photophobia, tearing, ciliary congestion, iris edema, pupil narrowing, fine posterior corneal deposits, and atrial clouding. Occasionally, anterior chamber inflammation is very severe, with fibrinoid exudate and pus accumulation in the anterior chamber. Visual acuity is usually mildly reduced and occasionally can cause macular cystoid edema, which can result in significant loss of vision. Acute uveitis may occur during the course of the disease in approximately 25-33% of patients with ankylosing spondylitis, and in 18%-34% of those with acute uveitis. Occasionally, vitreous inflammation can occur in patients with acute uveitis and ankylosing spondylitis, but it is significantly less likely to occur than typical iridocyclitis. Chorioretinitis, retinal vasculitis, or conjunctivitis may occur in individual patients. The examination reveals pericorneal congestion, iris edema, lighter iris pigment on the lesioned side compared to the healthy side, a narrowed pupil, and an irregular pupil if there are posterior chamber adhesions, especially in the presence of dilation. Slit lamp examination reveals massive anterior chamber exudation and small keratoconjunctivities. A single episode of uveitis often resolves after 4-8 weeks, but can recur in either eye. Although many other conditions can present with uveitis, once a patient presents with non-granulomatous anterior uveitis, ankylosing spondylitis or other spondyloarthropathies should be suspected. Treatment includes pupil dilation, heat and topical glucocorticoids, and in severe cases, systemic hormones. In recent years, TNF-α inhibitors have been reported to reduce the recurrence of uveitis while improving the symptoms of spondyloarthropathies.