1, about premature ejaculation – definition and classification At present, there is no uniform definition of premature ejaculation. True premature ejaculation refers to those who ejaculate immediately before entering or just entering the vagina. Most of the general literature includes cases with ejaculation latency <2min in the study. 2. about premature ejaculation - etiology The etiology of premature ejaculation has been debated for about a century, and the traditional view is that premature ejaculation is mostly psychological. Today's research focuses on the combined effect of both psychological and organic factors, but to date, no theory has been widely accepted for this reason. It is generally believed that persistent psychological factors may aggravate the underlying organic factors and cause premature ejaculation. Psychological factors such as anxiety, tension and anxiety play an important role, and it has been suggested that because sympathetic nerves play a key role in ejaculation. It has been suggested that sympathetic nerves play a key role in ejaculation, and that mental factors such as anxiety can increase sympathetic nerve activity and lower the ejaculatory threshold of the penile nerves. However, there is still no strong evidence to confirm this. 3, about premature ejaculation treatment - antidepressant medication antidepressant medication: it has been found that ejaculation disorder was found incidentally when antidepressants were given to psychiatric patients. There are experimental reports that the excitability of the ejaculatory center of the cerebral cortex can be increased by dopamine-based stimulation but inhibited by anti-5 a hydroxytryptamine stimulation, and that both anti-a-adrenergic receptors and proposed 5-a hydroxytryptaminergic receptors can delay ejaculation. In recent years antidepressants, adrenergic receptor blockers and 5-hydroxytryptamine reuptake inhibitors (SSRIs) have been widely used in the treatment of premature ejaculation, although these patients do not necessarily suffer from depression. These drugs are a safe alternative especially for those who are ineffective in psychotherapy, or who refuse to undergo psychotherapy, or whose sexual partners are unwilling to cooperate with treatment. The main antidepressants reported for premature ejaculation are tricyclic antidepressants (such as chlorpromazine, doxepin, etc.) and SsRI (including fluoxetine, sertraline, paroxetine, etc.), which have been shown in rigorous double-blind, randomized, placebo-controlled studies to significantly prolong ejaculatory latency, while SSRIs have mild side effects and less dosage than anxiolytics when used as sexual therapy, and thus have fewer side effects. 4, about premature ejaculation treatment - surgical treatment Surgical treatment: (1) dorsal penile neurectomy and (2) circumcision: after selective excision of the dorsal penile nerve, the sensitivity of the penile head can be reduced and the ejaculatory stimulation threshold can be increased, thus prolonging the ejaculatory latency and improving the quality of the patient's sexual life. Although its therapeutic effect has been recognized to a certain extent, its safety and effectiveness still need to be studied. 5, about premature ejaculation treatment - local treatment Local treatment: In the past, local treatment of premature ejaculation mostly used sprays and ointments with local anesthetics as main components, such as 1% dacronin ointment, 1% to 2% bupivacaine, 1% dicaine, 2% lidocaine, etc., which are applied to the glans penis before sexual intercourse to delay ejaculation latency through local anesthesia. Delay the latency of ejaculation by local anesthesia. SS-cream cream is a new drug made from natural drug extracts, which can raise the penile sensory threshold, reduce sensory nerve excitability, and increase penile blood flow to help erection. It increases blood flow to the penis and helps erection.