For the treatment of high total bilirubin, it is necessary to identify the cause of the disease before giving the corresponding treatment. If the cause is due to life and diet, the general conditioning can be enough, no need to use drugs; if the cause is due to disease, there are more choices of drugs, such as ursodeoxycholic acid capsule, bisacodyl tablets, entecavir and so on. 1. Dietary reasons: such as tiredness, late at night, drinking and other factors can lead to high bilirubin, general conditioning can be restored. 2. Disease causes: according to the specific disease with different drugs, such as cholestatic hepatitis can be given ursodeoxycholic acid capsules, bicyclic alcohol tablets and other drugs; such as viral hepatitis can be given entecavir, adefovir and other drugs; such as parasitic infections can be given albendazole, mebendazole and so on; such as acute cholecystitis can be given to the cefaclor, levofloxacin and other antibiotics. For high bilirubin, it is recommended to consult a doctor to clarify the cause of the disease before giving the corresponding treatment.