How to correctly view the “major and minor triplets” of hepatitis B virus?

  First, “major triple-positive” and “minor triple-positive”.  It is relatively easy to check whether you have hepatitis B virus infection. You only need to go to the hospital to have a blood test for hepatitis B and a half (or hepatitis B five). The two halves of hepatitis B are ① surface antigen (HBsAg), ② surface antibody (HBsAb), ③ e antigen (HBeAg), ④ e antibody, and ⑤ core antibody (HBcAb). Hepatitis B virus infection is often manifested as “major triple-positive” or “minor triple-positive”.  The so-called “major triple-positive” means that items ①, ③ and ⑤ are positive at the same time, which means that the virus is actively replicating in the human body and is highly infectious. The term “minor triple-positive” means that items ①, ④ and ⑤ are positive at the same time, or that items ① and ⑤ are positive at the same time, regardless of whether item ④ is positive. Generally speaking, “minor third-positive” means that the virus is not actively replicating and the virus level is not high, so it is less infectious or basically not infectious, and the disease is starting to improve. In addition, “small triple-positive” may also be due to virus mutation, and its significance is similar to that of “large triple-positive”.  Between “major triple-positive” and “minor triple-positive”, both have positive surface antigen and core antibody. The difference between the two is whether they are positive for e antigen or not. The difference between the two is whether they are e antigen positive or not. “Big three” is e antigen positive, while “small three” is e antigen negative.  Asymptomatic carriers and hepatitis B patients.  Asymptomatic carriers (referred to as carriers) are hepatitis B two-to-one half performance of “major three positive” or “minor three positive” and last for more than six months, no liver disease performance, liver biochemical function tests are normal. Hepatitis B patients are those who have a hepatitis B semi-positive test of “major triplet” or “minor triplet” and have liver disease or abnormal liver biochemical function tests. In short, if the liver function is normal, he/she is a carrier; if the liver function is not normal, he/she belongs to hepatitis B.  Carriers can get married and have children.  Hepatitis B virus is mainly transmitted vertically from mother to child (from mother to newborn) and through blood. The hepatitis B virus is not transmitted by sharing a meal together or through general daily contact. A carrier has the right to marry, but before marriage, the spouse should be checked. If the spouse is completely negative for hepatitis B, he/she should be vaccinated against hepatitis B and wait until he/she develops protective antibodies (surface antibodies) before getting married, or if the spouse is already positive for surface antibodies, he/she can get married at any time.  Carriers can have children normally, but should be medically counseled and evaluated beforehand for possible effects on the newborn. Regardless of whether the mother or father is a carrier, her newborn must be promptly vaccinated with hepatitis B highly effective immune globulin and hepatitis B vaccine within 24 hours of birth and complete the full course of hepatitis B vaccination according to the 0, 1, 2, 6 protocol (within 24 hours of birth, 1 month, 2 months, 6 months after birth). The efficiency of this program in preventing hepatitis B virus infection in newborns can be as high as 90% or more.  IV. Carriers enjoy the right to education and employment.  Carriers can enjoy the same rights as healthy people. Carriers and healthy people studying, working and living together usually do not transmit the hepatitis B virus, and they can share work and study supplies such as telephones, computers and books together. Carriers enjoy the same opportunities and rights to education as other students, except for those related to catering, childcare, police schools and military recruitment, which are not suitable for enrollment. Carriers can engage in most of the occupations, except that they cannot work in the catering industry or as childcare workers in childcare institutions, police officers or special military personnel.  V. Carriers do not need treatment for the time being.  For carriers, the most important concern is whether to carry out treatment. The current scientific attitude is to withhold treatment for the time being. The reason for this is twofold: (1) the virus in the carrier does not cause significant damage to the body itself. The “major triplet” and “minor triplet” are only a state of carriage of the hepatitis B virus, not a disease state. At this time, the virus and the human body coexist peacefully and do not interfere with each other, the virus does not cause obvious damage to the human body, and the human body cannot immune attack the virus to remove it.  (2) So far, there are no drugs that have a definite effect on carriers of “major triplets” and “minor triplets”, that is, they cannot clear the virus, nor can they prevent hepatitis activity after using certain drugs. Even the two most effective drugs against hepatitis B virus, alpha-interferon and Herceptin, are currently recognized as being unable to help. In other words, attempting to treat “major triplets” and “minor triplets” carriers with the so-called “negative” treatment will only be a waste of time and money for the vast majority of people.  Therefore, we urge those people with normal liver function who have “major threeyang” and “minor threeyang” not to rush to the doctor and not to be cheated by unscrupulous doctors, spending hundreds of dollars on meaningless “conversion” treatment. The “treatment”, and some drugs will also cause damage to the human body it!  Sixth, the carrier should pay attention to personal problems.  China’s existing about 120 million hepatitis B virus carriers, most of which have a relatively good prognosis, do not believe in any panacea to turn negative. If you follow up with the hospital regularly, you can be a healthy person. The majority of people who are carriers of “major triplets” and “minor triplets” will turn into hepatitis B. It is not yet possible to predict when this will happen, so it is important to follow up regularly. The liver function should be reviewed every 2-3 months for “major triple-positive” carriers and every 3-6 months for “minor triple-positive” carriers, and serum fetoprotein and liver ultrasound should be checked every six months for those over 40 years old to keep track of the evolution of the disease. If abnormalities in liver function occur, active treatment is required. The specific treatment plan should be developed by an experienced hepatologist.  On the other hand, fighting and clearing the hepatitis B virus requires a good immunity. Psychologically, a cheerful and optimistic attitude, a reasonable work and rest schedule, enough rest, and proper physical exercise are all necessary to maintain a good immunity. In addition, dietary regimen is also important, try to eat less high-fat diet and quit drinking, which can reduce combined fatty liver and alcoholic hepatitis. Finally, if carriers need medication for other diseases, they should try to avoid using drugs that may have liver damage.