We often encounter a wide variety of muscle pains in our daily life, in different parts, either mild or severe, most of which are related to cold and strain and recover quickly after rest or general treatment, with little impact on the quality of life. However, the causes of some of these muscle pains are more complex and should be taken seriously. Myalgia is a painful sensation in the muscle itself. The following is an introduction to muscle pain that should attract our attention: 1. Newly emerged muscle pain: such as distal muscle pain accompanied by fever, especially calf gastrocnemius pain, should be promptly consulted to exclude leptospirosis, parasites and other infectious diseases; such as the recent use of certain drugs, such as lipid-lowering drugs, antidepressants, antibiotics, etc. should be alert to drug-related myositis or rhabdomyolysis; such as in the hot summer environment If muscle pain occurs after physical work, rhabdomyolysis due to heatstroke should be excluded. Unilateral gastrocnemius pain is usually a local problem, such as deep vein thrombosis. 2. Slow onset muscle pain: generalized myalgia with weakness is usually due to inflammatory, metabolic, endocrine or toxic muscle disease, usually manifesting as pain in the upper arms and thighs. Diffuse myalgia is more common in rheumatic diseases. If accompanied by a rash on the eyelids, face and joints, a hospital visit should be made to test for autoantibodies and muscle enzymes to rule out dermatomyositis or polymyositis. If, in addition to myalgia, muscle weakness is more pronounced, accompanied by proptosis, weight loss, insomnia, etc., hyperthyroidism should be excluded. Rheumatic polymyalgia is mostly manifested as diffuse myalgia and unfavorable joint movement, back pain or shoulder and back pain is often more prominent, often accompanied by mild weight loss and low fever, and is common in elderly people over 50 years old, sometimes accompanied by temporal pain. In addition, some young and middle-aged women often feel sore, muscle stiffness, fatigue, and always have trouble sleeping, but the results of various tests are normal, may suffer from fibromyalgia syndrome. 3.Myalgia is mild but muscle weakness is obvious or accompanied by neurological symptoms: If the above-mentioned muscle pain occurs, you should promptly consult a doctor and improve relevant examinations, including blood routine, blood sedimentation, muscle enzymes, autoantibodies, electromyography, etc. If necessary, muscle biopsy should be performed to clarify the diagnosis as soon as possible. The appropriate treatment should be chosen according to different diseases, such as infectious diseases requiring antibacterial agents, dermatomyositis or polymyositis requiring hormones or immunosuppressive agents, and hyperthyroidism requiring antihyperthyroid treatment.