The first choice of drugs for Aspergillus chimaera infection can be ampicillin, cefotaxime, if allergic to such drugs, you can choose aminoglycoside antibiotics or chloramphenicol, etc., and can be combined with drugs for serious infections. However, the emergence of Aspergillus chimaera infection, you can not blindly use drugs on their own, you need to go to the hospital for examination first, follow the doctor’s instructions to use drugs according to the course. Aspergillus chimaera is a kind of Gram-negative bacillus, which is widely distributed in nature, human and animal intestines. It is a conditionally pathogenic bacterium, that is, under normal circumstances, A. oddis will not develop in the human intestine, but will only develop when the body’s immune system is low or the flora is dysbiosis. Most A. oddis does not usually produce beta-lactamase, so it is moderately sensitive to penicillin, sensitive to ampicillin and most cephalosporin antibiotics, sensitive to gentamicin, kanamycin, amikacin, and sensitive to chloramphenicol. A skin test is required before administration, and if this type of drug is allergic, other types of antibiotics, such as gentamicin and amikacin, can be substituted. If the infection is more serious, a combination of amikacin as well as cephalosporins can be used.