Lung cancer patients with chest tightness and cough are mainly caused by the enlargement or metastasis of lung tumor, which can be treated by oxygen inhalation, drugs and surgery. 1. Oxygen inhalation: when lung cancer patients have chest tightness and cough, there will be a certain degree of hypoxia, which can be relieved by oxygen inhalation to avoid the symptoms of respiratory distress and hypoxic coma. 2. Drug treatment: drugs such as gefitinib and erlotinib can be used to control the growth of cancer cells and alleviate the damage of cancer cells to lungs, while drugs such as cough suppressant and bronchial dilatation can be given to alleviate the symptoms of chest tightness and cough. 3. Surgical treatment: After lung cancer patients have chest tightness and cough and have the chance of surgery, it is recommended to perform surgical resection as soon as possible to remove the diseased tissues, so as to relieve the symptoms of chest tightness and cough. After lung cancer patients have chest tightness and cough, it is recommended to go to hospital as soon as possible and choose suitable treatment plan under doctor’s guidance to control the development of the disease and avoid affecting health.