Difficulty in breathing, chest tightness and shortness of breath with cough may be caused by pneumonia, COPD, asthma etc. It can be relieved by taking medication, etc. It needs to be analyzed specifically. 1. Pneumonia: the patient may have low resistance, bacteria and other pathogens invade the lung parenchyma, thus causing lung infections and symptoms such as dyspnea, chest tightness and shortness of breath with cough, etc. The patient can take antibiotics, such as amoxicillin, to relieve the symptoms. Antibiotics such as amoxicillin and moxifloxacin can be taken to relieve the symptoms. If coughing up phlegm, acetylcysteine nebulization can be given to expectorate. 2. Chronic Obstructive Pulmonary Disease (COPD): Patients may suffer from irreversible decline in lung function due to long-term smoking, resulting in COPD, which causes symptoms such as dyspnea, chest tightness, shortness of breath with cough, etc. The symptoms can be relieved by inhalation of β2-adrenergic acid. It can be relieved by inhalation of β2-adrenoceptor agonists such as terbutaline, or oral aminophylline, etc. Tiotropium bromide can be inhaled to control the condition in the long term. 3. Asthma: After contact with allergens such as dust mites, pollen, animal hair, etc., the patient will cause inflammatory reaction in the airway, resulting in asthma, with symptoms such as dyspnea, chest tightness, shortness of breath with cough, etc. The patient can inhale glucocorticosteroids to control the condition. Inhalation of glucocorticoid drugs such as beclomethasone and budesonide can be used to relieve the symptoms. In addition, there are other diseases that can cause dyspnea, chest tightness, shortness of breath with cough, if the symptoms are not relieved or aggravated, it is recommended to go to the hospital for examination, to clarify the specific causes of the disease, and under the guidance of the doctor to take medication as well as targeted treatment.