Men taking tadalafil for a long time can not treat premature ejaculation, tadalafil can treat penile erectile dysfunction, should be used under the guidance of a doctor. Tadalafil is a cyclic guanosine monophosphate specific phosphodiesterase inhibitor, which can promote blood flow into the penile tissue to make penile erection in the presence of sexual stimulation, clinically used to treat erectile dysfunction, but ineffective in the treatment of premature ejaculation. Tadalafil is contraindicated in people who are allergic to this drug and should not be combined with nitrate drugs such as isosorbide nitrate. Due to the potential risk of sexual intercourse to the heart, this drug is used with caution in people with underlying heart disease. Tadalafil use may cause adverse reactions such as headache, flushing, nausea, dyspepsia, back pain and myalgia. Seek medical attention if you feel unwell. Premature ejaculation is recommended to go to the urology department, and can be treated with psycho-spiritual treatment, as well as topical lidocaine spray or ointment, and taking medication such as dapoxetine. Drugs should be used under medical supervision.