Esophageal reflux can cause tachycardia and generally has a good prognosis after standardized treatment. Esophageal reflux is the main pathogenesis of gastroesophageal reflux disease (GERD), and the reflux is mostly gastric contents. Under the continuous stimulation of gastric contents, it can lead to acid reflux, heartburn, chest pain, belching, epigastric burning sensation and other discomforts, which can reflexively stimulate the sympathetic nerve excitation and lead to accelerated heart rate, therefore, esophageal reflux can cause tachycardia. For the treatment of GERD, the main methods currently adopted in the clinic are lifestyle changes and medication. Lifestyle change can be carried out by quitting smoking, quitting alcohol, light and nutritious diet, appropriate physical exercise, etc. Meanwhile, avoiding excessive satiety is conducive to the improvement of patients’ clinical symptoms. Pharmacological treatment is generally the use of antacids, drugs to promote gastrointestinal dynamics, drugs to protect the gastric mucosa, etc. Some patients may be combined with varying degrees of anxiety, and antidepressants can be added if necessary. Because of the risks associated with drug therapy, it is safer to use drugs under the guidance of a professional physician, and after active treatment, the general prognosis is good.