Umbilical bulge-giant tongue-giant body syndrome is an autosomal recessive disorder that occurs in the offspring of consanguineous marriages, and its pathogenesis is not well understood. Some people measured the plasma insulin concentration of four children and found that all of them had a significant increase. It is believed that the hyper-secretory function of the hyperplastic pancreatic β-cells and hyperinsulinemia are the basis of hypoglycemia; some people believe that the relatively insufficient function of pancreatic α-cells and impaired glycogenolysis may also be the cause of hypoglycemic episodes. Clinically, both sexes can develop the disease. After birth, the child shows many deformities, and the physical appearance is significantly larger than that of a normal newborn, with a huge tongue that often sticks out of the mouth; the clumsy movement affects the normal nursing action and bite. The mouth is not enlarged often with an enlarged abdomen umbilical bulge or umbilical hernia. In the first month after birth, the child may be emaciated, and the subcutaneous fat is obviously reduced, but in the following months, the growth is gradually accelerated and even close to the giant deformity, until about 1 week of age, the child shows slurred speech, speech disorders, jaw protrusion to the front, and hypoglycemic attacks as the prominent symptom of the disease can appear within a few hours after birth, and later on, there are repeated attacks of severe cases of convulsions and loss of consciousness blood glucose, which can be less than 1.1mmol/L. Hypoglycemic attacks occur after birth. Hypoglycemic episodes are most frequent in the first month after birth, and then gradually decrease, and generally stop after 3 to 4 months, but there are also those who last until 2 to 3 years old, but there are also those who do not have hypoglycemic episodes, according to statistics, the incidence of hypoglycemia accounts for about 33% to 50% of visceral hypertrophy is also common, such as liver, kidney, pancreas, heart and other disproportionate hypertrophy, in addition, there can also be facial flame-like mother spot, auricular deformity, facial central hypoplasia, diaphragmatic defects, clitoral hypertrophy, cryptorchidism, intestinal torsion, as well as maternal amniotic fluid overload and giant fetuses. The child has mild mental retardation and microcephaly. If the child survives to the pediatric stage, hemiplegia may be present, and he is often prone to malignant tumors such as adrenal adenoma, Wilms’ tumor, seminoma, hepatoblastoma, and abdominal tumors. Treatment of hypoglycemia is difficult to maintain blood glucose to normal level with glucose intravenous injection or intravenous drip alone, but can only raise blood glucose temporarily, if corticosteroids are added at the same time, blood glucose can be stabilized. or umbilical hernia, plastic surgery can be used.