Anemic nevi differ from leukoplakia in appearance, symptoms, preferred sites, and treatment. Anemic nevi are caused by congenital skin vascular abnormalities, resulting in increased sensitivity to catecholamines and causing constriction of restricted blood vessels. Vitiligo is of different sizes and shapes with clear borders and will turn porcelain white after a long time, while nevus pigmentosus is a light-colored spot with different sizes and fuzzy jagged borders; 2. Different symptoms: when rubbing the lesion of nevus pigmentosus or stimulating the lesion with hot or cold, the plaque area will not become red. The sensation of anaplastic nevus is normal, but it remains unchanged for life after the occurrence of lesions. The lesions of vitiligo generally have no uncomfortable symptoms, but will gradually expand, hair whitening may occur, a few patients will have slight itching and discomfort, pathological examination will show a decrease in melanocytes; 3, different locations: anemic nevus is found on the face, neck and buttocks, and is mostly unilateral, vitiligo can appear in all parts of the body, anaplastic nevus is found on the chest and back and limbs; 4, different treatment: anemic nevus Generally no treatment is needed, if you feel that it affects the beauty, you can have cosmetic treatment. Vitiligo needs glucocorticoid treatment in the early stage, and phototherapy is preferred in the stable stage. No pigmented nevus treatment is not effective, usually can take autologous epidermal transplantation.