Yellowish green or greenish brown skin is mostly a symptom caused by jaundice. In acute hemolysis, there may be fever, chills, headache, vomiting, back pain, and varying degrees of anemia and hemoglobinuria (soy sauce or tea-colored urine), and in severe cases, acute renal failure. Chronic hemolysis is mostly congenital, with splenomegaly in addition to anemia. So what is the clinical basis of the examination? Total serum bilirubin is increased, mainly unconjugated bilirubin, and conjugated bilirubin is basically normal. Due to the increase of unconjugated bilirubin in blood, the formation of conjugated bilirubin also increases compensatingly, and the excretion from bile duct to intestine also increases, resulting in the increase of urobilinogen and the subsequent increase of fecal bilirubin and the deepening of fecal color. Urobilinogen in the intestine increases, and the reabsorption to the liver also increases. Due to the effect of hypoxia and toxins, the ability of the liver to process the increased urobilinogen than normal is reduced, resulting in an increase of urobilinogen in the blood and its excretion from the kidneys, so there is an increase of urobilinogen in the urine, but no bilirubin. In acute hemolysis, hemoglobin is excreted in the urine and the occult blood test is positive. In addition to anemia, blood tests also show an increase in reticulocytes and a hyperplasia of the bone marrow red blood cell series.