It is not true that there is no first choice of three drugs for kidney failure. The treatment for patients with kidney failure should be decided according to the cause and condition. Drugs for treating primary disease, drugs for treating complications and drugs for preserving kidney and detoxification can be chosen. 1. Drugs for treating primary disease: It is necessary to evaluate the primary disease and choose the appropriate drug treatment. Glucocorticosteroids such as prednisone and immunosuppressants such as cyclophosphamide and tacrolimus should be chosen according to the type of pathology and clinical symptoms of the patient. 2. Drugs for treating complications: sodium bicarbonate for acidosis treatment; iron and recombinant human erythropoietin for anemia treatment; and drugs for correcting electrolyte disorders, which need to be chosen according to the specific situation. 3. Kidney-protecting and detoxifying drugs: kidney-protecting drugs, such as Bailing capsule, Jinshuibao capsule, etc.; detoxifying drugs, such as urethane granules, renal failure tablets, etc.. In addition, the application of drugs have a certain risk, the patient needs to go to the hospital, under the guidance of a specialist in the use of medication.