There are many parents who are concerned about whether their children will get type 1 diabetes, especially those who have type 1 diabetes themselves. Here are some of the ways in which this can be explained Immune-mediated. 100% of patients with type 1 diabetes develop at least one B cell-related autoantibody such as ICA, IAA, GAD, and tyrosine phosphatase antibodies in the preclinical period. insulin antibody (IAA) is the first antibody to appear in type 1 patients, and if it is consistently positive, there is a greater chance of developing diabetes later. However, it is unclear whether it is a marker of immune damage or a predictor of the onset of the disease. The data show that about 10% of people with immunodeficiency develop diabetes, which indicates that immunodeficiency is the basis and that acquired factors play a large role. Genetic factors. type 1 diabetes is hereditary. 10-15% of first-degree relatives of people with type 1 diabetes will develop diabetes. This is significantly higher than in the general population. The most closely related to type 1 diabetes is currently the leukocyte-associated antigen HLA-II class I molecule. HLA is a genetic locus on the chromosome, and genetic variants in this region are closely related to the inheritance of type 1 diabetes. When the gene is expressed in a haplogroup consisting of HLA-DR3, DQ2 or DR4, DQ8, 90% will develop type 1 diabetes. So when parents are unsure they can check your child’s HLA genotype. Environmental factors. The prevalence of type 1 diabetes in identical twins of the same genetic background is less than 50% consistent, suggesting that environmental factors have an important influence. Studies have shown that viral infections may be associated with the onset of the disease, and some children have been seen to develop the disease in association with viral infections, for example, a single upper respiratory infection can trigger the disease. This suggests the need to avoid viral infections in life, as much as possible. Secondly, studies have shown that early use of cereals or gluten can increase the risk of developing type 1 diabetes. Take care to minimize the intake of cereal and gluten foods in early childhood. Studies on the risk of developing type 1 diabetes from milk consumption have had mixed results, and it is prudent to try not to consume milk too early. The age factor is also important. The high prevalence of type 1 diabetes is at the age of 11 —-14. People at risk in this age group should pay particular attention to environmental factors and try to avoid exposure to the above environmental factors to reduce their chances of developing the disease. Finally, if your child unfortunately ends up with diabetes parents should not lose faith, with the development of technology, we have more and more means to deal with the challenge of type 1 diabetes. We have seen many children with type 1 diabetes grow up to be physically and mentally healthy and achieve success in their careers, and I have come into contact with children who have gone abroad to study and make a career out of it. Finally, I wish you and your children the best of luck!