Cerebral arteriovenous malformations, especially large arteriovenous malformations, pose great difficulties and obstacles to clinical treatment because of the wide range of malformed masses, many blood supplying arteries, thick draining veins and many deep venous drains. Craniotomy often leads to fatal hemorrhage or serious sequelae affecting the quality of life of patients, therefore, craniotomy is not recommended as the first choice for treatment of large arteriovenous malformations. Minimally invasive interventional embolization treatment involves injecting liquid embolic material into the nest of the malformed vessel through a special microcatheter system to stop the flow of blood through the nest, thus achieving a cure. However, it is almost impossible to completely cure a large, giant arteriovenous malformation with a single or several embolizations. Radiosurgery Gamma Knife treatment requires a malformed vascular mass of less than 3 cm in diameter and is powerless against large giant arteriovenous malformations. However, is it true that large arteriovenous malformations are hopeless and incurable? The answer is obviously no! With the advancement of medicine today, various surgical techniques, equipment, interventional materials and devices have improved the treatment of large arteriovenous malformations. Combined minimally invasive interventions with craniotomy and gamma knife treatment offer the possibility of curing large arteriovenous malformations. Usually, the majority of the malformed vascular mass is embolized by minimally invasive interventions first, and then the residual part is treated by surgical resection or gamma knife, and satisfactory results can often be achieved. Of course, to achieve satisfactory results requires extensive clinical experience and individualized treatment plans.