Creatine is a nitrogen-containing organic acid that can be synthesized by the body itself or ingested from food. Moderate consumption can increase the concentration of creatine in skeletal muscle, thus increasing the concentration of creatine phosphate, which in turn can help to restore fatigue and increase strength. Usually, taking creatine does not affect sexual function, but if taken in large amounts over a long period of time, it may have the side effect of weight gain, which in turn may have an indirect effect on sexual function. If the patient is a male, obesity will affect the secretion of gonadotropin-releasing hormone, luteinizing hormone and follicle-stimulating hormone, which in turn will affect the function of testicular interstitial cells and supporting cells, impede the release of sex hormones and interfere with the formation and maturation of sperm, thus affecting the patient’s sexual function. Obesity is also highly associated with erectile dysfunction in men, which can easily lead to impotence, premature ejaculation and other undesirable conditions. If the patient is a woman, obesity will promote gonadal hormone secretion and increase the level of androgens in the body, thus affecting female libido, while obesity can also make the sexual function of women with pelvic floor dysfunction worse. To sum up, if creatine is not taken reasonably, it will have a certain impact on sexual function, so it should be taken in the right amount and consult a professional. The daily supplementation of high quality protein, dietary cholesterol, some trace elements, minerals and vitamins can be used to regulate the diet structure and improve sexual function.