Azithromycin is the drug of choice for the treatment of pediatric pneumonia, with strong tolerability, less likely to have adverse reactions after taking the drug, and the drug can be absorbed by the blood of the child, with low side effects, short efficacy, and less likely to be repeated. Azithromycin can treat pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae and Mycoplasma pneumoniae infection. In the process of applying azithromycin to treat pneumonia, cough suppressant, expectorant, antipyretic, wheezing and anti-allergic drugs should be applied in combination, and its efficacy is remarkable. Pediatric pneumonia is one of the most common respiratory diseases in infants and young children. Due to the poor immunity of children, it is easy to develop in winter and spring. Pediatric pneumonia needs to be detected and cured in a timely manner, and once the best treatment is delayed, it may cause recurrence of the disease and is not easily curable.