The therapeutic drugs for liver metastasis after colon cancer surgery include chemotherapeutic drugs such as oxaliplatin and capecitabine; targeted drugs such as cetuximab and bevacizumab; and liver-protecting drugs such as compound glycyrrhizin tablets. 1. Chemotherapeutic drugs: chemotherapy can be used to kill tumor cells when liver metastasis occurs after colon cancer surgery, and commonly used drugs include oxaliplatin, capecitabine, 5-fluorouracil, formyltetrahydrofolate, irinotecan and so on. 2. Targeted drugs: Targeted drug treatment for metastatic colon cancer is also more effective, which can inhibit the proliferation and metastasis of cancer cells. Commonly used drugs include cetuximab, bevacizumab and so on. 3. Liver protection drugs: patients with liver metastasis after colon cancer surgery may have abnormal liver function, so they can use drugs such as compound glycyrrhizin tablets, liver protection tablets and glucuronolactone tablets to protect the liver. Patients should follow the doctor’s instruction to use the drugs, do not blindly use the drugs by themselves to avoid adverse reactions.