Acne nodules refer to nodular acne, which is a severe form of acne that may appear as dark red nodules of varying sizes, accompanied by pain and discomfort. Common treatments include medication, physical therapy, etc. The doctor should determine the appropriate and effective treatment according to the patient’s condition. Oral isotretinoin is an important treatment for nodular acne, which can reduce sebum secretion and regulate the abnormal keratinization of follicular sebaceous gland ducts. When inflammation is obvious, oral antibiotics such as minocycline and doxycycline can be prescribed first. For severe nodular acne, intradermal injection of glucocorticosteroids such as tretinoin injection can be used as an adjunct. Nodular acne can be supplemented with topical medications, such as adapalene, benzoyl peroxide, azelaic acid, etc., along with systemic medications. Patients should follow the doctor’s instructions to avoid stopping the medication on their own, which may lead to recurrence of symptoms. If necessary, physical therapy such as photodynamic therapy can be combined to promote the disappearance of nodules. Patients with nodular acne should consult a doctor for targeted treatment.